NAD+ therapy has become one of the most talked-about treatments in the IV therapy world. Promoted for its potential anti-aging, energy-boosting, and brain-enhancing properties, NAD+ infusions command premium prices and generate strong word-of-mouth from clients who swear by the results. But what exactly is NAD+, and does the science support the enthusiasm?
This guide covers everything you need to know about NAD+ IV therapy — from the basic biology to the current state of research, practical considerations, and realistic expectations.
What Is NAD+?
NAD+ stands for nicotinamide adenine dinucleotide. It is a coenzyme found in every living cell in your body and plays a critical role in hundreds of metabolic processes. At its most fundamental level, NAD+ is involved in:
- Energy metabolism — NAD+ is essential for converting food into cellular energy (ATP) through the mitochondria
- DNA repair — Enzymes called sirtuins depend on NAD+ to repair damaged DNA and regulate gene expression
- Cellular signaling — NAD+ participates in cell-to-cell communication and stress response pathways
- Circadian rhythm regulation — NAD+ levels fluctuate throughout the day and influence sleep-wake cycles
The problem is that NAD+ levels decline naturally with age. Research suggests that by the time a person reaches their 50s, NAD+ levels may be roughly half of what they were in their 20s. This decline has been linked to many hallmarks of aging, including reduced energy, slower recovery, cognitive changes, and increased vulnerability to age-related diseases.
How NAD+ IV Therapy Works
NAD+ IV therapy delivers the coenzyme directly into the bloodstream, bypassing the digestive system entirely. This is significant because oral NAD+ supplements have very limited bioavailability — most of the NAD+ is broken down in the gut before it ever reaches the bloodstream.
A typical NAD+ IV session involves:
- A slow-drip infusion lasting 2 to 4 hours (NAD+ must be administered slowly to avoid side effects)
- Dosages ranging from 250mg for introductory sessions to 500mg or even 1000mg for full treatment protocols
- Monitoring by a licensed nurse or medical professional throughout the infusion
- Initial protocols of 2 to 4 sessions over consecutive days, followed by monthly maintenance
The longer infusion time compared to standard IV drips is because NAD+ administered too quickly can cause chest tightness, nausea, and an intense flushing sensation. Experienced providers know to adjust the drip rate based on the patient's tolerance.
Potential Benefits of NAD+ Therapy
Proponents of NAD+ therapy report a range of benefits. The most commonly cited include:
Increased Energy and Reduced Fatigue
Because NAD+ is directly involved in mitochondrial energy production, replenishing depleted levels may help restore cellular energy. Many clients report feeling more energetic and less fatigued after completing an NAD+ protocol, with some describing it as a general sense of vitality they had not felt in years.
Improved Mental Clarity
Brain cells have exceptionally high energy demands. NAD+ supports neuronal energy metabolism and may promote the function of sirtuins, which play roles in neuroprotection. Clients frequently report improved focus, reduced brain fog, and sharper thinking after NAD+ treatment.
Anti-Aging and Cellular Repair
The anti-aging angle is where much of the scientific interest lies. NAD+ activates sirtuin proteins — sometimes called longevity genes — that are involved in DNA repair, inflammation regulation, and cellular stress resistance. Animal studies have shown promising results with NAD+ precursors extending healthspan in mice, though human trials are still in progress.
Addiction and Recovery Support
Some clinics have used NAD+ therapy as part of addiction recovery programs, particularly for alcohol and opioid dependence. The theory is that NAD+ helps restore neurotransmitter balance and cellular function damaged by substance abuse. While client testimonials are often positive, large-scale clinical trials specifically for this application are limited.
Athletic Performance and Recovery
Athletes interested in optimizing recovery have turned to NAD+ therapy as a way to support mitochondrial function and reduce oxidative stress from intense training. The connection between NAD+ and cellular repair mechanisms makes this a plausible application, though rigorous sports medicine studies are still needed.
What Does the Research Say?
NAD+ research is one of the most active areas in aging biology. Here is where things stand:
- Animal studies — Numerous studies in mice have shown that boosting NAD+ levels with precursors like NMN and NR can improve metabolic health, extend healthspan, and reverse some markers of aging. These results have generated enormous scientific excitement.
- Human clinical trials — Several clinical trials are underway studying NAD+ precursors (NMN and NR) in humans. Early results have confirmed that these supplements can raise blood NAD+ levels in humans. However, translating the dramatic results seen in mice into clear clinical benefits in humans remains a work in progress.
- IV-specific research — Studies specifically examining IV NAD+ delivery (as opposed to oral precursors) are limited. Most of the published human research focuses on oral NMN or NR supplements rather than intravenous NAD+ itself.
The gap between promising animal research and confirmed human benefits is important to acknowledge. NAD+ therapy shows real potential, but it is still in the early stages of clinical validation for many of its claimed benefits.
Who Should Consider NAD+ Therapy?
NAD+ therapy may be worth exploring if you:
- Are experiencing age-related fatigue or declining energy levels
- Want to optimize cognitive performance and mental clarity
- Are interested in proactive anti-aging strategies
- Are an athlete looking to improve recovery and mitochondrial function
- Have tried oral NAD+ precursors (NMN, NR) and want to explore IV delivery for better bioavailability
NAD+ therapy is not recommended for pregnant or nursing women, individuals with certain cardiovascular conditions, or anyone who has not discussed it with their physician. As with any IV therapy, a proper medical screening should be completed before treatment.
How Much Does NAD+ Therapy Cost?
NAD+ infusions are among the most expensive IV treatments available. Expect to pay:
- $250 to $500 per session for a standard 250mg dose
- $500 to $750 for higher doses (500mg+)
- $1,500 to $3,000 for a full initial protocol (typically 4 sessions over consecutive days)
- $300 to $500 per month for maintenance infusions
The higher cost reflects both the expense of pharmaceutical-grade NAD+ and the extended infusion time required. For a broader pricing overview, check our IV therapy cost guide.
Finding a Qualified NAD+ Provider
Because NAD+ infusions are more complex than standard IV drips — longer duration, specific drip rate requirements, and potential side effects — choosing a qualified provider is especially important. Look for:
- Experienced nursing staff who have administered NAD+ infusions before
- A physician medical director overseeing the treatment protocol
- NAD+ sourced from a licensed compounding pharmacy (503A or 503B)
- Clear information about dosing, expected duration, and potential side effects
Search our directory for NAD+ therapy providers in your area. Our guide on choosing an IV therapy provider covers additional factors to consider.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. NAD+ therapy is a wellness service currently under active research. Claims about anti-aging and disease prevention should be evaluated critically. Always consult your healthcare provider before beginning NAD+ or any IV therapy program.