The Myers' Cocktail is the most widely administered IV vitamin infusion in the United States. Developed by Dr. John Myers, a Baltimore physician, in the 1960s, this formula has been used for decades to treat a range of conditions from chronic fatigue to migraines. Today it is the flagship offering at most IV therapy clinics and mobile providers — if a company offers IV therapy, they almost certainly offer a Myers' Cocktail.
This guide covers what's in the Myers' Cocktail, the conditions it's used for, what the research says, how much it costs, and what to expect if you decide to try it.
What's in a Myers' Cocktail?
The standard Myers' Cocktail contains a specific combination of vitamins and minerals dissolved in sterile saline solution:
- Magnesium chloride — supports muscle function, nerve signaling, and energy production. Magnesium deficiency is common and linked to migraines, muscle cramps, and fatigue
- Calcium gluconate — essential for bone health, muscle contraction, and nerve function
- Vitamin B-complex — a group of B vitamins (B1, B2, B3, B5, B6) that support energy metabolism and nervous system health
- Vitamin B12 (hydroxocobalamin) — critical for red blood cell production, neurological function, and DNA synthesis. Many people are deficient, especially vegetarians and older adults
- Vitamin C (ascorbic acid) — a powerful antioxidant that supports immune function, collagen production, and iron absorption
Some providers modify the classic formula by adding extras like glutathione (an antioxidant), zinc, or higher doses of specific vitamins. These variations are often marketed under different names — "Super Myers'," "Enhanced Myers'," or "Myers' Plus" — but the core ingredients remain the same.
What Conditions Does It Treat?
The Myers' Cocktail has been used to address a wide range of health concerns. The most common reasons people seek this treatment include:
- Chronic fatigue and low energy — the B vitamins and magnesium directly support cellular energy production
- Migraines and tension headaches — magnesium has well-documented benefits for migraine prevention and acute treatment
- Seasonal allergies and asthma — Dr. Myers originally used this formula for asthma patients, and magnesium has bronchodilator properties
- Fibromyalgia — some patients report reduced pain and improved energy levels
- Upper respiratory infections — high-dose vitamin C and zinc support immune response during illness
- General wellness and prevention — many clients use it as regular maintenance, similar to a multivitamin but with full bioavailability
- Hangover recovery — the combination of hydration, B vitamins, and magnesium addresses multiple hangover symptoms simultaneously
What Does the Research Say?
The evidence base for the Myers' Cocktail is growing but still limited compared to pharmaceutical interventions. Here is what we know:
A 2009 pilot study published in the Journal of Alternative and Complementary Medicine found that Myers' Cocktail infusions improved quality of life and reduced tender points in fibromyalgia patients compared to placebo. A 2019 case series showed improvement in chronic fatigue symptoms in 75% of patients receiving regular Myers' infusions.
The individual ingredients are better studied. IV magnesium is used in emergency medicine for acute asthma and eclampsia. High-dose IV vitamin C has been studied extensively in oncology settings. B12 injections are a standard treatment for pernicious anemia.
The main limitation is the lack of large, randomized controlled trials specifically on the Myers' formula as a whole. Most evidence comes from case reports, small studies, and clinical observation. This does not mean the treatment is ineffective — it means the formal research has not caught up with decades of clinical use.
What to Expect During Treatment
A Myers' Cocktail session typically takes 30 to 60 minutes. Here is what the process looks like:
- Intake — the provider reviews your health history and current symptoms. Some providers require a brief consultation on your first visit
- IV placement — a registered nurse or paramedic inserts a small IV catheter, usually in the arm. This is the same type used for any standard IV
- Infusion — the Myers' solution drips into your bloodstream over 30 to 60 minutes. You can read, work on your phone, or relax during this time
- Post-treatment — the IV is removed and you are free to go. There is no downtime required
During the infusion, you may notice a warm, flushed feeling — this is caused by the magnesium and is completely normal. Some people taste vitamins in the back of their throat. A small number of people feel lightheaded briefly, which is why most providers keep you seated during the drip.
How Much Does a Myers' Cocktail Cost?
Pricing varies by location and provider type:
- IV clinics and bars: $150 to $250 per session
- Mobile IV providers: $175 to $300 per session (includes travel fee)
- Concierge and luxury providers: $250 to $400 per session
- Membership plans: Many providers offer monthly memberships at $99 to $199/month that include one or more Myers' sessions
The Myers' Cocktail is generally one of the most affordable IV treatments available, especially compared to NAD+ infusions ($300 to $1,000+) or specialty formulations. For a full pricing breakdown, see our 2026 IV therapy cost guide.
How Often Should You Get a Myers' Cocktail?
There is no single answer — it depends on your goals and health status:
- Acute symptoms (migraine, cold, hangover): one session as needed
- Chronic conditions (fatigue, fibromyalgia): weekly sessions for 4 to 6 weeks, then reassess
- General wellness: every 2 to 4 weeks for ongoing maintenance
- Athletes and high performers: weekly during heavy training, biweekly otherwise
Most providers will discuss a treatment plan during your first visit and adjust frequency based on how you respond.
Side Effects and Safety
The Myers' Cocktail has an excellent safety profile when administered by trained medical professionals. Potential side effects include:
- Warm or flushed feeling during infusion (from magnesium — normal and temporary)
- Mild bruising at the IV insertion site
- Brief lightheadedness
- Rare: allergic reaction to a specific ingredient
Serious complications are extremely uncommon. The most important safety factor is who administers the treatment. Always verify that your provider uses licensed medical professionals (registered nurses, paramedics, or physicians) and sources pharmaceutical-grade ingredients from licensed compounding pharmacies.
Myers' Cocktail vs. Other IV Treatments
How does the Myers' compare to other popular IV options?
- vs. Basic Hydration ($99-$150): Hydration drips are saline only. The Myers' adds vitamins and minerals for additional benefits beyond rehydration
- vs. NAD+ ($300-$1,000+): NAD+ therapy targets cellular aging and brain health specifically. The Myers' is broader-spectrum and more affordable
- vs. Hangover IV ($150-$250): Many hangover drips are essentially a Myers' Cocktail with added anti-nausea medication. Read more in our hangover IV therapy guide
- vs. Beauty/Glutathione ($200-$350): Beauty drips focus on skin health with glutathione and biotin. Some providers offer a Myers' with added glutathione as a combo
For most first-time IV therapy clients, the Myers' Cocktail is the recommended starting point. It covers the broadest range of benefits at a moderate price point.
Finding a Provider
IV therapy is available both at dedicated clinics and through mobile providers who come to your home, office, or hotel. Both options offer the same treatment — the choice comes down to convenience and personal preference.
Browse IV therapy providers near you to compare Myers' Cocktail options in your area. You can filter by treatment type and check provider credentials. For guidance on what to look for, read our provider selection guide.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. The Myers' Cocktail is a wellness treatment and should not replace professional medical care. Consult your healthcare provider before starting any new health regimen, especially if you have kidney disease, heart conditions, or are taking medications that affect electrolyte levels.